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KMID : 1102220240430010111
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Kidney Research and Clinical Practice
2024 Volume.43 No. 1 p.111 ~ p.121
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Effectiveness of regdanvimab on mortality in COVID-19 infected patients on hemodialysis
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Kee Youn-Kyung
Park Hayne Cho
Yoon Su-Jin
Yu Sung-Bong
Ko Eun-Sil
Cho A-Jin
Kim Do-Hyoung
Kim Jin-Seog
Lee Young-Ki
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Abstract
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Background: Although several therapeutic agents have been evaluated for the treatment of coronavirus disease 2019 (COVID-19), there are lack of effective and proven treatments for end-stage renal disease (ESRD). The present study aims to evaluate the effectiveness of regdanvimab on mortality in COVID-19?infected patients on hemodialysis (HD).
Methods: We conducted an observational retrospective study in 230 COVID-19?infected patients on HD, of whom 77 (33.5%) were administered regdanvimab alone or in combination with dexamethasone or remdesivir during hospitalization (regdanvimab group) and 153 patients (66.5%) were not (no regdanvimab group). The primary outcome was in-hospital mortality. We compared mortality rates according to the use of regdanvimab and investigated the factors associated with mortality.
Results: Fifty-nine deaths occurred during hospitalization, 49 in the no regdanvimab group (32.0%) and 10 in the regdanvimab group (13.0%), and the mortality rate was significantly higher in the no regdanvimab group than that in the regdanvimab group (p = 0.001). Multivariate Cox regression analysis showed that malignancy (p = 0.001), SPO2 of <95% at admission (p = 0.003), and administration of antibiotics and regdanvimab (p = 0.007 and p = 0.002, respectively) were significantly associated factors with mortality.
Conclusion: Regdanvimab administration is beneficial in improving prognosis in hospitalized COVID-19 patients on HD. Considering the vulnerability to infection and high mortality of ESRD patients, regdanvimab may be considered as a therapeutic option in COVID-19 patients on HD.
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KEYWORD
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COVID-19, Renal dialysis, Mortality, Regdanvimab
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